WELCOME TO CAPTIVATE

The broadly protective malaria vaccine combination

ABOUT CAPTIVATE

The CAPTIVATE project (Correlates of protective immunity-driven investigation of malaria vaccine combination strategies), supported by the European Union’s Horizon Europe research and innovation programme, brings together experts from Europe and Australia in an integrated interdisciplinary approach aimed at developing the next generation of malaria vaccines to the clinic.

The Consortium will be supported by an independent Scientific and Ethics Advisory Committee (SEAC) to facilitate the achievement of the established objectives, playing a crucial role in providing strategic input on scientific, technical, and ethical issues.

At a glance

TIMELINE

1 November 2023

to 30 April 2028

FUNDER

European Comission

COORDINATOR

European Vaccine Initiative (EVI)

FUNDING

€8.2 Million

Plasmodium falciparum, the deadliest malaria parasite, remains a severe global health threat. In 2022, 249 million cases and 608,000 fatalities were reported, with children under 5 constituting 78,1% of malaria-related deaths in the WHO African Region. Despite years of dedicated efforts within the scientific community to develop malaria vaccines, there are still important challenges to tackle.

STRATEGY

To pursue our mission, an innovative vaccine development program will be set up consisting of combination vaccine approaches covering multiple parasite life cycle stages, traditional immunological analyses, innovative single immune cell sequencing, and artificial intelligence (AI) to assist in the understanding of the mechanisms of adaptive protective immunity.

IMPACT

From generating new scientific knowledge on malaria field to developing a more effective vaccine, the CAPTIVATE project holds the potential to significantly impact various aspects of scientific, economic, technological, medical, and societal domains.

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